The Krebs cycle (also known as the citric acid cycle or the tricarboxylic acid cycle) takes place inside the mitochondria. The Krebs cycle enzymes are located in the mitochondrial matrix. In prokaryotes, all Krebs cycle enzymes are located in the cytosol. All mitochondrial enzymes except succinate dehydrogenase and alpha-ketoglutarate dehydrogenase are also outside the mitochondria. Oxaloacetate is consumed in the first reaction of the cycle and produced in the last reaction. Therefore, oxaloacetate has a catalytic role in this cycle. The Krebs cycle is aerobic. Lack of oxygen completely inhibits the Krebs cycle, and oxygen deficiency (hypoxia) causes its relative inhibition.
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